Matteo Berrettini Eltern is a professional tennis player from Italy. He reached a career high ATP singles ranking of No. 8 on November 4, 2019, and a career high ATP doubles ranking of No. 105 on July 22, 2019.At the 2021 Queens Club Championships, he won his first ATP 500-level event. After receiving a wildcard in the pre-qualifying wildcard round, Berrettini made his ATP main draw debut at the Italian Open. In the first round, he was defeated by Fabio Fognini. He was the top seed in an eight-man Italian field competing for a berth in the first Next Generation ATP Finals in Milan, however he was defeated in straight sets by Filippo Baldi.

Berrettini won his second ATP singles title at the Hungarian Open, defeating Filip Krajinovi in the final. Berrettini kept his run going the next week, reaching the final of the Bavarian International Tennis Championships. Cristian Garn broke his nine-match winning streak in a third-set tie-breaker there. Berrettini defeated Alexander Zverev in the final of the Italian Open.Berrettini pulled out of the next two events in Gstaad and Montreal because to an ankle ailment.Before competing in the US Open, he competed in a warm-up tournament in Cincinnati. Berettini made his first Major quarterfinal after overcoming Andrey Rublev in the fourth round, despite his lack of preparation. He subsequently defeated Gael Monfils in a fifth-set tiebreak to become the first Italian male to win a Grand Slam singles title.

Berrettini defeated Andrew Harris before losing to Tennys Sandgren at the Australian Open after withdrawing from the 2020 ATP Cup due to physical issues. He won the Ultimate Tennis Showdown when the tour was shut down and reopened due to the COVID-19 pandemic. In Cincinnati, he was defeated in the third round by Reilly Opelka.He advanced to the fourth round of the US Open without dropping a set. After retiring from the 2020 ATP Cup due to physical concerns, Berrettini overcame Andrew Harris before losing to Tennys Sandgren at the Australian Open. When the tour was shut down and reopened due to the COVID-19 pandemic, he won the Ultimate Tennis Showdown. Reilly Opelka defeated him in the third round in Cincinnati.Without dropping a set, he got to the fourth round of the US Open.

Berrettini is a hard-hitting all-court player with a powerful serve and forehand. His forehand, which is famed for its speed, spin, and depth, is his primary weapon. He also has a powerful serve, capable of reaching speeds of up to 235 km/h (146 mph). With aggressive play and creating pressure on his opponent, Berrettini concentrates on setting up quick points and smashing winners. His transitional and net game are both excellent.

Born in Rome to Luca Berrettini and Claudia Bigo, Matteo Berrettini has a younger brother, Jacopo, also a tennis player.His maternal grandmother, Lucia Fogaça, is a Brazilian from Rio de Janeiro.His paternal grandfather is from Florence. He is fluent in Italian, English, and Spanish. He is in a relationship with Australian tennis player Ajla Tomljanović.Aldo Cazzullo, director of the newspaper Corriere della Sera, has criticized Berrettini (along with other young Italian tennis players, including Jannik Sinner and Lorenzo Musetti) for moving his residency to Monaco for financial benefits.